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Written by Patrick Moser, FNP-BC
Information last reviewed 06/21/19
Sildenafil is a prescription medication in the class PDE5 inhibitor. Commonly known as Viagra, is one of the most frequently prescribed oral medications for the treatment of erectile dysfunction. It comes in 25, 50, and 100 mg tablets. Sildenafil is also available as a 20 mg tablet, known as Revatio, which is generally used to treat pulmonary hypertension.
Sexual stimulation causes the release of nitric oxide (NO) into the corpus cavernosum of the penis, which increases blood flow into the penis and causes an erection. In a man with ED, this process is interrupted by a chemical called phosphodiesterase type 5 (PDE5). Sildenafil works by blocking the effects of PDE5 and allows the process to continue uninterrupted. Put simply, Sildenafil increases the amount of blood flow into the penis to achieve an erection when a man is sexually stimulated.
Several studies have proven that the use of sildenafil results in successful completion of sexual intercourse for 60 to 80 percent of men with ED. There are other treatment options available for those who do not respond to sildenafil.
The active ingredient in each Sildenafil pill is sildenafil citrate. Sildenafil citrate may be included in the following quantities, depending upon the pill strength selected: 25mg, 50mg,100 mg.
The inactive ingredients in Sildenafil include cellulose, calcium phosphate, magnesium stearate, silicon dioxide, hydroxypropyl cellulose, polyethylene glycol, titanium dioxide, and artificial colors.
Please note: The inactive ingredients may vary between different manufacturers of generic medications.
Sildenafil would very rarely cause a severe allergic reaction unless you have a specific allergy to sildenafil. Signs and symptoms of an allergic reaction include rash, trouble breathing, itching/swelling, and dizziness. If you notice any of these symptoms, you should get immediate medical help.
Sildenafil comes in 25, 50, or 100 mg tablets. Most men require 50 mg or 100 mg to achieve the desired results. However, some men respond appropriately to the 25 mg dose. Many providers will prescribe 25 or 50 mg initially, then titrate up as needed, to a maximum dose of 100 mg daily.
Sildenafil should be taken approximately 1 hour before sexual activity. However, Sildenafil has been effective within 30 minutes or up to 4 hours after it is taken. The timing of the effects can vary depending on the individual’s response to treatment.
When used as a treatment for ED, Sildenafil should not be taken more than once a day. Although it can be taken daily, it is generally prescribed to be used as needed only before sexual intercourse.
People who take Sildenafil may experience the following mild to moderate side effects:
More serious side effects can include:
You should not take Sildenafil if you:
Sildenafil can interact with some other medications, causing increased or decreased effects of either medication. Some of these drugs are:
You should not take Sildenafil if you have been drinking alcohol. Always make sure to tell your doctor what other medications you are taking before starting Sildenafil.
There are several different options for treating erectile dysfunction. In addition to Sildenafil, there are other medications such as Cialis or Levitra. Another option may be to use a mechanical device, such as vacuum devices and penile implants. There is also a medication called Alprostadil that can be injected into the penis to help achieve an erection.
Greenstone is a manufacturer of Sildenafil. Unlike most generic manufacturers, Greenstone is owned by Pfizer - the original manufacturer of Viagra. Therefore, Greenstone Sildenafil contains exactly the same active and inactive ingredients as Viagra, but at a fraction of the cost.
Greenstone Sildenafil even has the same shape as Viagra (a rounded diamond shape), but instead of the iconic blue color, it is a white tablet. Greenstone Sildenafil is the ideal option for people who want the reliability of a reputable brand without the high price tag.
Cialis (Taladafil) is also a popular medication for the treatment of erectile dysfunction. Cialis works on the same mechanism of action as Sildenafil. It also has similar side effects and contraindications. The biggest difference between Cialis and Sildenafil is the amount of time the medication is effective. While the effects of Sildenafil last about 4 hours, Cialis can last almost 36 hours before the effects wear off. Sildenafil has been reported to have a slightly higher, approximately 3 percent, satisfaction rate compared to Cialis, and Cialis is much more expensive than Sildenafil. For the price, Sildenafil looks like a pretty good option.
One of the actions of testosterone, a hormone produced in the testicles, is the maintenance of sexual function. Although low testosterone levels do not cause erectile dysfunction, there is evidence to suggest that testosterone replacement therapy can improve the problem. Transdermal testosterone replacement, or replacement of testosterone using a topical gel that absorbs into the skin, is more effective than getting Testosterone injections or taking an oral testosterone supplement. Although the replacement of testosterone can be helpful in the treatment of erectile dysfunction, combining it with Sildenafil does not increase the effects of the medication.
Sildenafil will not cause an erection in the absence of sexual stimulation. The stimulation is what causes the release of nitric oxide, which ultimately leads to an erection. Sildenafil does not have an effect on the release of nitric oxide. Sildenafil does not in itself cause or heighten sexual stimulation.
Sildenafil can be taken with or without food. However, meals with a high-fat content can cause a delay in the effects of Sildenafil. Grapefruit and grapefruit juice may interfere with the way Sildenafil works. Alcohol can also have an impact on the effectiveness of Sildenafil.
Generally speaking, Sildenafil is safe for long-term use. Studies have proven both effectiveness and safety for up to 3 years (studies have not extended past the 3-year point). Patient safety and satisfaction have been proven over time in clinical practice settings as well.
Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.
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