Hydroxyzine Pamoate (Vistaril)

Buy hydroxyzine online to help relieve insomnia

Hydroxyzine is an antihistamine that can be used to relieve the symptoms of insomnia and help you regain a better quality of life.

Hydroxyzine Pamoate (Vistaril)
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30 tablets
60 tablets
90 tablets
Best value
Medzino Lemonaid Health
$35 $60
$70 $120
$105 $180
Comparison of Medzino subscription prices to other online providers.
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Reviewed by Dr Roy Kedem, MD

Information last reviewed 03/26/21


What is hydroxyzine pamoate?

Hydroxyzine pamoate is a prescription medication used to relieve the symptoms of insomnia, a common sleep disorder that makes it difficult to sleep, stay asleep, or get good quality sleep. It is in a class of medications called antihistamines. Hydroxyzine is available by prescription only. 

What is hydroxyzine used for?

Hydroxyzine is used to treat a wide range of conditions such as insomnia, anxiety, itching, mood problems, an upset stomach, and others. 

How does hydroxyzine (Vistaril) work?

Hydroxyzine works by blocking histamine, a naturally occurring substance that is produced by the body. It also decreases activity in the central nervous system which can cause drowsiness and make you sleepy.

How long does hydroxyzine last?

Hydroxyzine is rapidly absorbed and its effects can be seen within 15 to 30 minutes of taking the capsule. Its effects typically last from 4 to 6 hours.

Who should avoid taking hydroxyzine

Hydroxyzine should not be taken by individuals who are allergic to hydroxyzine or any other ingredients. Individuals with a history of QT prolongation or other significant arrhythmias should not take hydroxyzine. It is also not recommended for women in early pregnancy or nursing mothers. 

Hydroxyzine vs Xanax

Hydroxyzine and Xanax are both considered off-label treatments for insomnia. These medications are part of two different classes and therefore, work differently. Hydroxyzine is an antihistamine while Xanax is a benzodiazepine. Like many other benzodiazepine medications, studies have shown that Xanax has a high addiction potential and can cause withdrawal symptoms. Hydroxyzine does not share these risks.

Hydroxyzine vs Benadryl

Hydroxyzine and Benadryl can both be used as off-label treatments for insomnia. Both medications are antihistamines, meaning they work by blocking histamine, resulting in sedative effects. However, hydroxyzine requires a prescription from a licensed physician while Benadryl can be purchased over the counter. Hydroxyzine and Benadryl should only be used to treat short-term insomnia as they can become less effective over time.

Hydroxyzine hydrochloride (hcl) vs pamoate

Hydroxyzine hydrochloride and hydroxyzine pamoate are both antihistamines and work by similar mechanisms. Hydroxyzine hcl is typically used to provide relief for allergies and itching while hydroxyzine pamoate is more commonly used to treat anxiety.


Active Ingredient

The active ingredient in hydroxyzine is hydroxyzine pamoate at a concentration of 25mg, 50mg, or 100mg. 

Inactive Ingredients

The inactive ingredients of hydroxyzine can vary between different brands of the medication. The branded version of hydroxyzine is Vistaril and is manufactured by Pfizer Labs. The inactive ingredients in the capsule form of Vistaril include: hard gelatin capsules, magnesium stearate, sodium lauryl sulfate, starch, and sucrose.  


What dosage is hydroxyzine pamoate available in?

Hydroxyzine pamoate is available in the following dosages: 25mg, 50mg, or 100mg. The recommended dosages for the treatment of insomnia are only 25mg or 50mg. 

How to take hydroxyzine (Vistaril)?

For treating insomnia, one tablet of hydroxyzine should be taken by mouth daily before bedtime. It can be taken with or without food. It is important that you do not operate a vehicle or other heavy machinery after taking hydroxyzine. Always follow the directions provided by your doctor.

Side Effects

Hydroxyzine side effects

Common side effects of hydroxyzine include:

  • Drowsiness
  • Headache
  • Dry mouth
  • Skin rash

If any of these side effects persist or cause discomfort, talk to your physician.

Seek medical attention right away if you experience any of the following serious side effects:

  • Rapid heartbeat
  • Headache with chest pain
  • Severe dizziness
  • Fainting
  • Seizures

Treatment Options

What are some treatment options for insomnia?


Type Accessibility Intended Treatment

Hydroxyzine (Vistaril)

Antihistamine Prescription needed Short-term insomnia

Trazodone (Desyrel)

SSRI Prescription needed Chronic insomnia

Alprazolam (Xanax)

Benzodiazepine Prescription needed (controlled substance) Short-term insomnia

Dipenhydramine (Benadryl)

Antihistamine Over the counter Short-term insomnia



Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.

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