Lisinopril (Zestril)

Manage your blood pressure with Lisinopril (Zestril)

Lisinopril is an ACE inhibitor that can treat high blood pressure and heart failure. It works by relaxing your blood vessels, which widens them and hence lowers blood pressure.

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Medicine Quantity Strength Price
Lisinopril90 tablets2.5mg$14.00
Lisinopril90 tablets5mg$15.00
Lisinopril90 tablets10mg$16.00
Lisinopril-HCTZ90 tablets10-12.5 mg$19.95
Lisinopril90 tablets20mg$17.00
Lisinopril-HCTZ90 tablets20-12.5 mg$19.95
Lisinopril-HCTZ90 tablets20-25 mg$19.95
Lisinopril90 tablets30mg$23.00
Lisinopril90 tablets40mg$25.00
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Information

Written by Dr Kim Langdon, MD

Information last reviewed 07/15/19

About

What is Lisinopril?

Lisinopril is a type of high blood pressure treatment called an angiotensin-converting enzyme inhibitor or ACE inhibitor. It is also used to treat heart failure. Angiotensin causes the blood vessels to constrict, thus raising the pressure against the walls. Think of a river during white water rafting. When the width narrows, the water speeds up and applies more pressure/turbulence. When the river widens, the flow becomes slower, meaning less force against the banks.

How does Lisinopril work?

Lisinopril is a type of high blood pressure treatment known as an ACE inhibitor (angiotensin-converting enzyme inhibitor). Angiotensin causes the blood vessels to constrict, thus raising the pressure against the walls. Think of a river during white water rafting. When the width narrows, the water speeds up and applies more pressure/turbulence. When the river widens, the flow becomes slower, meaning less force against the banks. By reducing the conversion of substances into angiotensin, Lisinopril helps to prevent the increase in blood pressure associated with angiotensin. 

How long does Lisinopril take to work?

Lisinopril will take action after about 1 hour of the dose, and the peak effect is at about 6 hours after the dose.  The duration of effect is about 24 hours.

How effective is Lisinopril?

Lisinopril can be very effective in managing high blood pressure. Occasionally, your doctor may have to increase the dose to achieve the desired effect.  In addition, Lisinopril and other medications of the ACE inhibitor class have been shown to improve outcomes in some patients with heart failure by modulating the neurohormonal system of the heart and kidneys.

Ingredients

Active ingredients

The active ingredient in Lisinopril is lisinopril. Lisinopril is an ACE inhibitor. This means that it works preventing the conversion and lowering the secretion of certain substances in the body which reduces sodium (salt) and water retention in the body. Where sodium goes, water follows. So if you take in too much salt, the water from the tissues travels into the blood to balance the salt. By preventing too much water from entering the blood, the volume inside the blood vessels is reduced, which lowers blood pressure. But in addition, the reduction in sodium allows the blood vessels to dilate, further reducing blood pressure.

Inactive ingredients

The inactive ingredients are: Calcium phosphate, mannitol, magnesium stearate, and starch. The 10 mg and 20 mg tablets also contain iron oxide.  

Dosage

Dosage

Lisinopril doses start at 2.5mg once daily. Depending upon how you respond, your dose may be increased to 5mg or as much as 40mg once a day.

How to take Lisinopril

Lisinopril can be taken with or without food, and is given as a single dose daily.

What should I do if I miss a dose?

If you miss a dose of Lisinopril, you should take the dose as soon as possible, unless you are within 12 hours of your next dose. Taking doses within 12 hours of each other or taking too much Lisinopril can be dangerous.

Side Effects

Side Effects

Side effects of Lisinopril include:

  • Swelling
  • Cough
  • Chest pain
  • Low blood pressure
  • Dizziness
  • Rashes
  • Hives
  • Headache
  • Diarrhea
  • Fatigue
  • Nausea

Contraindications

Lisinopril is not suitable for you if you have any of the following conditions:

  • Hypersensitivity to Lisinopril or ACE inhibitors
  • Renal artery stenosis (narrowed artery to the kidney)
  • Aortic stenosis
  • Coarctation of aorta
  • Pregnancy

Special Precautions while taking Lisinopril

Lisinopril should be prescribed and used with caution if you suffer from the following conditions:

  • Renal impairment
  • Cardiogenic shock
  • Severe heart failure
  • Anesthesia
  • Surgery

Interactions for Lisinopril

Lisinopril can have negative interactions with other drugs including the following:

  • Antacids: Lowered efficacy of Lisinopril.
  • Indomethacin: Reduces desired effect.
  • Digoxin : Increases plasma digoxin levels.
  • Potassium preparations & Potassium-sparing diuretics
  • Lithium: Increases serum concentration of Lithium.
  • Immunosuppressive Drugs: Increased risk of bone marrow depression.
  • Antidepressants
  • Diuretics
  • Beta-Blockers
  • Phenothiazines
  • Morphine

Q&A

Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.

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