Grapefruit and grapefruit juice can interact with Amlodipine. Amlodipine is broken down by enzymes (CYP3A4) in the lower intestine. People have different levels of these enzymes in their body, so eating grapefruit can affect people differently, even when they both take Amlodipine. Eating grapefruit can block the action of these important enzymes. This causes the drug to stay around for longer, allowing too much Amlodipine to enter your bloodstream. These higher levels of Amlodipine mean stronger effects of the drug and stronger side effects.
What happens if I eat grapefruit while taking Amlodipine?
Eating grapefruit while on Amlodipine can cause the same side effects as if you were taking a much higher dose of the drug. Severe cases of dizziness, headaches, vomiting, joint pain, tiredness are possible, as well as liver and muscle damage leading to kidney failure in severe cases.
Can I eat citrus fruit while taking Amlodipine?
Grapefruits are the main fruit to avoid when taking Amlodipine, including red, pink, white and oro blanco varieties. Seville oranges (used in orange marmalade), pomelos and tangelos (a cross between tangerines and grapefruits) may also have similar effects, so it is best to avoid these fruits when taking amlodipine.
- FDA- https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm292276.htm