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Reviewed by Dr Roy Kedem, MD
Information last reviewed 07/12/21
Nystatin cream is an antifungal medication used to treat infections caused by yeast. Nystatin comes in various forms (powder, tablets, cream), but the cream version is intended to treat skin infections specifically.
Yeast infections are caused by Candida fungi. This fungus is normally present on the skin and is kept in balance by the immune system and the barrier of intact skin. However, when this balance is disturbed, the fungus can replicate very quickly, resulting in a yeast infection. This balance can be disturbed by various factors, including stress, antibiotic use, skin abrasion, excessive perspiration and more.
Nystatin cream stops the growth of the infection-causing fungus by destroying the fungus' cell membrane and cell walls. With these crucial structures compromised, the fungal cells die and are therefore unable to replicate.
Nystatin cream can be safely applied anywhere on your body with the exception of the following areas: vagina, mouth, eyes, and inside the nose.
It is important to note that nystatin cream is not to be used for vaginal yeast infections. If you are experiencing a vaginal yeast infection, we do offer specific treatment which you can access using this link.
Nystatin cream should not be used by individuals who are allergic to any of the medication’s ingredients.
Similar to nystatin, ketoconazole is also an antifungal cream used to treat skin infections. However, nystatin cream specifically treats infections caused by yeast, while ketoconazole treats systemic fungal infections.
Ketoconazole is also an antifungal medication. It can be applied topically and is often used in shampoos to treat scalp infections.
Unlike Nystatin, Ketoconazole can be prescribed as an oral medication to treat serious systemic fungal infections, although it has mostly been supplanted by safer alternatives.
The active ingredient in nystatin cream is nystatin with 100,000 USP units per gram.
The inactive ingredients in nystatin cream include polysorbate 60, algeldrate, titanium dioxide, glyceryl monostearate, PEG-8 Stearate, silicon dioxide, sorbic acid, propylene glycol, ethylenediamine, sorbitol, methylparaben, propylparaben, hydrochloric acid, petrolatum, and water.
Inactive ingredients and concentrations may vary between different manufacturers.
Nystatin cream should be applied as directed by your doctor. Typically, a thin layer is applied to cover the affected area twice daily. For best results:
The area should be cleaned and thoroughly dried before applying.
The medication should be applied at the same time every day.
Your hands should be washed thoroughly after application.
Nystatin usually starts working after two days. However, it is important to complete your course of treatment as prescribed by your doctor, even if symptoms begin to disappear before you're done with treatment.
Stopping treatment early may allow the fungus to continue to replicate and may cause the infection to return.
If you miss an application, apply the medication as soon as you remember. If it is almost time for your next application, skip the missed application and resume your usual schedule. Do not apply two doses at a time to catch up.
Side effects have been reported in less than 0.1% of patients using nystatin cream.
Common side effects may include:
Speak to your doctor if any of these side effects cause severe discomfort or persist.
Burning is a common side effect reported in patients using nystatin cream. The burning sensation should typically resolve within a few days as your body adjusts to the medication. If the burning continues to cause considerable discomfort, please speak with your doctor.
Nystatin cream is not available over the counter. This medication requires a prescription from a licensed doctor. You can order Nystatin cream directly from Medzino, and one of our doctors will review your medical information to make sure the medication is right for you before issuing a prescription. Click on the big pink button that says "Start your consultation" to get started with your order.
The safety of Nystatin cream in pregnancy has not been adequately evaluated. Nystatin cream can be prescribed for a pregnant woman only if your doctor determines that the potential benefits outweigh the risks.
Nystatin cream is often prescribed to treat a diaper rash due to yeast, in babies. If you believe your child may have a diaper rash, please consult with your pediatrician so that they can help you determine the best course of action.
Like all medications, nystatin cream has an expiration date. When you receive your medication, please be sure to check the expiration date. Do not use the medication past the expiration date indicated.
Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.
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