This article is about Bupropion 150mg, an FDA-approved medication for smoking cessation. If you are thinking about quitting smoking, doctors at Medzino can issue a prescription for Bupropion.
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Written by Dr Yasmin Aghajan, MD
Information last reviewed 06/21/19
Bupropion is one of the FDA approved medications for smoking cessation. Many smokers desire to quit, and using the available treatments gives them a better chance of being successful. The combination of behavior modifications, behavior counseling, and medications significantly improves the chance of success. Some of the barriers to quitting include Nicotine withdrawal symptoms and cravings. Bupropion has been shown to help with these symptoms, in combination with Nicotine replacement.
The exact mechanism of how Bupropion works for smoking cessation is not known, but it is thought to be related to modulation of noradrenergic and dopaminergic neurotransmission. The medication was first used to treat depression, but due to reports of people having decreased cravings for cigarettes while being treated for depression with Bupropion, the manufacturer studied the drug for use in smoking cessation.
Each tablet contains 150 mg of bupropion hydrochloride.
The inactive ingredients in Bupropion are: carnauba wax, cysteine hydrochloride, hypromellose, magnesium stearate, 625 microcrystalline cellulose, polyethylene glycol, polysorbate 80, and titanium dioxide and is 626 printed with edible black ink. In addition, the 150-mg tablet contains FD&C Blue No. 2 Lake 627 and FD&C Red No. 40 Lake.
Bupropion is dosed 150mg daily. After three days, the dose may be increased to 150mg twice a day (maximum 300mg/day). However, if this is not tolerated due to side effects as discussed below, the lower dose of 150mg a day has been shown to be effective. Bupropion does not have to be taken with meals. Bupropion must be swallowed whole (do not chew or crush tablets).
Treatment should begin at least two weeks before your target quit date (while still smoking, because it takes 1-2 weeks for the drug to start being effective). If you successfully quit smoking after 7-12 weeks, may consider continuing Bupropion as maintenance therapy afterwards for up to 1 year. On the other hand, if there is no progress after the seventh week of treatment, then Bupropion is not likely to work, and your provider can consider stopping this medication.
You should take Bupropion as prescribed by your doctor. The dose for smoking cessation is 150mg daily or 150 mg twice a day. It must be started 1-2 weeks before the planned “quit date” as the medication takes that long to start working. It does not need to be taken with food. The tablets should be taken whole, not chewed or crushed.
When used for smoking cessation, serious neuropsychiatric events have occured in patients taking Bupropion. These include mood changes (depression, mania), psychosis, hallucinations, paranoia, delusions, homicidal thoughts, agitation, suicidal thoughts and suicide attempts. These symptoms may be related to nicotine withdrawal. These effects happened in patients both with and without psychiatric conditions (such as depression). It is important to stop taking Bupropion and contact a health care provider if any side effects occur.
Bupropion is also used to treat psychiatric disorders such as depression. The medication carries psychiatric warnings when used to treat psychiatric disorders, including suicidal thinking/behaviors especially in young adults.
Bupropion should not be used if you have a history of seizures, epilepsy, or are stopping alcohol use suddenly as it can increase the risk of seizures.
Bupropion may cause mild pupil dilation, which can cause an episode of narrow-angle glaucoma in susceptible patients.
The most common side effects (>10%) include:
Bupropion has the potential to interact with the following medications:
Bupropion is contraindicated in the the following patients:
Studies of pregnant women who took Bupropion during the first trimester did not show any increased risk of birth defects. However, it has not been studied extensively and there is no long-term data. Bupropion should only be used in pregnancy if the benefit justifies the potential risk to the fetus. The long-term effect on development and behavior of Bupropion has not been studied.
Bupropion is present in breast-milk. Seizures and sleep disturbances were reported in breastfeeding infants whose mothers were using Bupropion, and infants should be closely monitored. However, the use of bupropion is not considered a contraindication to breastfeeding. The risks and benefits of breastfeeding should be discussed with your doctor.
Bupropion was first approved on the US market in 1985. It was approved for smoking cessation in 1997.
Bupropion is available as a generic medication, from multiple manufacturers such as Mylan, Sandoz, Novo. However, the brand name Zyban is made by GlaxoSmithKline.
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