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Written by Dr Yasmin Aghajan, MD
Information last reviewed 06/21/19
Fluconazole, sold under the brand name Diflucan, is a medication used to treat vulvovaginal yeast infections, which is an infection by a fungus called “candida” that causes itching and irritation of the genitals.
Yeast infections are very common. Classic symptoms include itching of the vulva (the most common symptom), pain, redness or irritation of the vulva or vagina, pain with urination, pain during sex, and abnormal vaginal discharge. The fungus that causes yeast infections normally lives in the vagina and in the gut. Many people have the fungus, but it does not cause any problems. Sometimes, antibiotics, stress or other factors can make the fungus grow more than it should and cause a yeast infection. Fluconazole works to treat yeast infections by stopping the fungus from growing.
Fluconazole is an anti-fungal medication. It works by inhibiting fungus from reproducing.
The active ingredient in Fluconazole is the anti-fungal agent, Fluconazole at a concentration of 150mg.
Fluconazole also contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, povidone, croscarmellose sodium, FD&C Red No. 40 aluminum lake dye, lactose and magnesium stearate. Inactive ingredients may vary between manufacturers.
If you have a lactose allergy or a deficiency that affects your lactose metabolism, you should avoid this medication as it contains lactose as an inactive ingredient. You should also let your doctor know of any other allergies you have to ensure they do not prescribe you a medication that can trigger an allergic reaction.
Always take Fluconazole exactly as prescribed by your doctor.
To treat vaginal yeast infections, Fluconazole is given as a single one-time dose of 150mg. This is because one tablet will have high concentrations in the vaginal fluids for at least 3 days after taking it. There is no dose adjustment for kidney disease for the single dose.
The infection should respond to treatment within a few days.
If you are pregnant, you should not take oral Fluconazole.
Always take Fluconazole as prescribed by your doctor. To treat vaginal yeast infections, Fluconazole is given as a one time single dose of 150mg tablets. It does not have to be taken with or without food.
If you have severe symptoms, history of complicated fungal infections, poorly controlled diabetes, or immunosuppression, you should not take Fluconazole 150mg to treat yeast infections. You may require stronger or prolonged treatment.
Do not take if pregnant or planning to become pregnant. Yeast infections in pregnancy are treated differently.
Fluconazole is generally well-tolerated, but some people may experience headaches (13%), dizziness, nausea (7%), abdominal pain (6%), diarrhea (1%), and abnormal taste in your mouth (1%).
The co-administration of Fluconazole with other medicines may interact with the effects of Fluconazole, or these other medicines. This is the list of medications that are known to interact with Fluconazole. Always inform your doctor of all the drugs and supplements you take.
It is contraindicated to take Fluconazole in the following cases:
Fluconazole was first introduced to the market in 1988.
Fluconazole is available as a generic medication from multiple manufacturers such as Mylan, Taro, Teva, Riva, and others. However, the original Flucnazole, or Diflucan, is manufactured by Pfizer.
No. Do not take Fluconazole oral tablets while pregnant or trying to become pregnant. Talk to your doctor about other options to treat vaginal yeast infections during pregnancy.
Current World Health Organization recommendations state that Fluconazole is compatible with breastfeeding.
Fluconazole and Miconazole are both anti-fungal treatments, but they have different active ingredients (fluconazole and miconazole). Fluconazole is commonly prescribed as an oral tablet, whereas Miconazole is usually a topical cream that is applied directly to the affected skin.
Fluconazole is an anti-fungal treatment, not an antibiotic. Antibiotics treat bacterial, not fungal, infections.
After taking Fluconazole orally, it is absorbed quickly and fully in the gastrointestinal tract.
Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.
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