Hydrochlorothiazide side effects
What are the most common side effects of Hydrochlorothiazide?
- Tingling feelings in your hands, legs and feet
- Poor appetite
- Dry mouth / increased thirst
- Erectile dysfunction (in men)
Rare side effects of Hydrochlorothiazide
Some rare but serious side effects can also occur from taking Hydrochlorothiazide:
- Severe skin reaction (Stevens-Johnson syndrome)
- Kidney failure
- Blurred vision
For a full list of side effects, please see the patient information leaflet provided with your medication.
Hydrochlorothiazide drug interactions
Hydrochlorothiazide can interact with a number of medications, including:
- Muscle relaxants
- Pain killers
- Medications for diabetes
- Chemotherapy agents
Therefore, for your own safety, it is essential that you let your doctor know if you are taking any other medications.
Hydrochlorothiazide should not be used by anyone who is allergic to Hydrochlorothiazide or other sulfonamide-derived medications such as Sulfamethoxazole. Hydrochlorothiazide should be used with caution in people with the following conditions:
- Kidney disease
- Liver disease
- Bronchial asthma
- Systemic lupus erythematosus.
Why is Hydrochlorothiazide contraindicated in diabetes?
Diabetes is a common contraindication for Hydrochlorothiazide. The prolonged use of thiazide diuretics like Hydrochlorothiazide may cause diabetes by causing glucose intolerance. It is also possible that Hydrochlorothiazide results in the increased production of glucose from the liver, another factor that might lead to diabetes.
Can you take Hydrochlorothiazide when you're pregnant?
Studies in mice and rats have not found Hydrochlorothiazide to cause any damage to the fetus. However, for ethical reasons, no reliable human studies have been undertaken to examine the effects of Hydrochlorothiazide in pregnancy. Therefore, it is recommended that Hydrochlorothiazide is avoided during pregnancy unless the benefits of treatment would outweigh the risks.
Hydrochlorothiazide, can you drink alcohol while taking it?
Patients commonly ask if they can drink alcohol when taking Hydrochlorothiazide. A reduction in alcohol intake while taking Hydrochlorothiazide is recommended, as alcohol itself can lower blood pressure. Coupled with alcohol, Hydrochlorothiazide can cause blood pressure to drop too low, which may make you feel dizzy or faint.
Will Hydrochlorothiazide lower blood pressure?
Hydrochlorothiazide is most commonly prescribed to reduce blood pressure, although it can be prescribed for other purposes. It is effective in lowering blood pressure in people with hypertension (high blood pressure).
HCTZ and breastfeeding
Hydrochlorothiazide can pass into breast milk. Therefore a decision may need to be made about whether to discontinue breastfeeding and to continue taking Hydrochlorothiazide or to stop taking Hydrochlorothiazide and to continue breastfeeding. Your doctor should be able to help you weigh the pros and cons before making this decision.
Will Hydrochlorothiazide lower heart rate?
A study looking into the effects of blood pressure medication on heart rate found that Hydrochlorothiazide can lower the heart rate over time.
Can Hydrochlorothiazide cause gout?
A common side effect of thiazide diuretics like Hydrochlorothiazide is hyperuricemia. Hyperuricemia is a term used to describe an increase in uric acid levels in the blood. Increased uric acid levels can lead to gout. Diuretics, such as Hydrochlorothiazide, reduce the rate of urate excretion and increase urate reabsorption in the kidneys, thus leading to hyperuricemia and gout.
Can Hydrochlorothiazide cause hair loss?
A known side effect of Hydrochlorothiazide is hair loss and hair thinning. This side effect can be temporary or permanent.
Can Hydrochlorothiazide cause weight gain?
A study conducted comparing weight gain properties of different medications concluded that Hydrochlorothiazide and other diuretics do not cause weight gain and can actually cause weight loss.
Can Hydrochlorothiazide cause weight loss?
The above study concluded that Hydrochlorothiazide and other diuretics can result in moderate weight loss of about 0.4-2.7kg. However, people experience different side effects when taking Hydrochlorothiazide, so weight loss might not be seen in everyone taking the medication.
Can Hydrochlorothiazide cause depression?
A nationwide Dutch study conducted between 2005 and 2015 found that there is no link between diuretics and an increased risk of depression. The study identified nine blood pressure medications that actually lowered the risk of depression, but Hydrochlorothiazide was not one of these drugs. None of the 41 drugs studied caused an increased risk of depression.
Can Hydrochlorothiazide cause leg cramps?
Like other diuretics, Hydrochlorothiazide can cause leg cramps. This occurs as diuretics deplete sodium and fluid levels in the body. They also cause a loss of potassium, calcium and magnesium, leading to cramps.