Perindopril is a type of high blood pressure treatment known as an ACE inhibitor. Perindopril can also be used to treat coronary artery disease and heart failure. If you have previously been prescribed Perindopril for high blood pressure, you can order a repeat supply from Medzino.
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Written by Dr Kim Langdon, MD
Information last reviewed 29/07/19
Perindopril is used in the management of hypertension (high blood pressure. Perindopril can be used alone or combined with other high blood pressure medications, such as amlodipine. Perindopril is in the category of ACE (angiotensin-converting enzyme) inhibitors. ACE inhibitors such as perindopril arginine and perindopril erbumine lower blood pressure by reducing the constriction (tightening) of blood vessels that is caused by a substance called angiotensin II. This means that Perindopril allows the blood vessels to relax and widen, reducing your blood pressure. Because Perinodpril widens the blood vessels, it can also be used to treat heart failure and coronary artery disease (CAD). In CAD the arteries that supply blood to the heart are narrowed, which causes angina (chest pain).
Perindopril is an ACE inhibitor. This means that it interferes with the processes that allow a substance called angiotensin I to turn to angiotensin II. Angiotensin II causes blood vessels to constrict and narrow, increasing blood pressure. By interferring with the converison of angiotensin I into angiotensin II, Perindopril reduces the amound of angiotensin II in the body, meaning that blood vessels are able to relax and widen, reducing your blood pressure.
Perindopril also helps to lower your blood pressure in another way. It reduces the levels of a hormone called aldosterone, which in turn, reduces the levels of water and sodium in the body. This has the effect of reducing your blood pressure.
The active ingredient in Perindopril is perindopril erbumine (Aceon) or perindopril arginine (Coversyl or Coversum). Both perindopril erbumine and perindopril arginine are considered equally effective for the treatment of high blood pressure.
The inactive ingredients in Perindopril are silicon dioxide, lactose monohydrate, magnesium stearate, and cellulose (microcrystalline), but inactive ingredients can vary between different brands of drug.
You must always take Perindopril as instructed by your doctor – never take more than your specified dose. Swallow the medicine whole with a glass of water – do not crush, chew or break the tablets. Perindopril is most effective when taken on an empty stomach as more of the dose is absorbed into the bloodstream. The medication may cause dizziness in some users; for this reason, your doctor may advise you to take your first dose at bedtime. If you do not experience any dizziness, it is recommended that you take your dose at the same time each morning, ideally 30 to 60 minutes before breakfast.
Initially, take 4mg a day. This will be increased by your doctor every two weeks, up to a maximum of 16mg a day, to ensure you get the right dose. You should take your medication at the same time every day, ideally in the morning. However, Perindopril is available in 2mg, 4mg and 8mg tablets and your doctor may advise you to take your Perindopril in several doses over the course of the day.
For Coronary Artery Disease (CAD), initially take 4mg a day. This will be increased every two weeks up to a maximum of 8mg a day. You should take your medication at the same time each day, but your doctor may allow you to take your medication in smaller doses over the course of the day.
If you forget a dose of Perindopril, you should take it as soon as you can, unless it is less than 12 hours until your next dose is due. You should not double-dose or take two doses close together, as this could cause dangerous side effects and lower your blood pressure to unsafe levels.
There are 9 disease interactions with perindopril:
Mylan, Sandoz, Teva, Actavis
No, you must have a doctor’s prescription
Yes, but it isn’t common accounting for about 1% of users
Yes, other ACE Inhibitors like enalapril, lisinopril, ramipril, captopril, quinapril, and imidapril are more common. Below is a list of the Brand names (Upper case letters) and generics (Lower case letters)
No, Perindopril is an ACE-inhibitor. Both beta blockers and ACE-inhibitors can lower your blood pressure, but they work on different mechanisms to do this.
No, Perindopril is used to reduce your blood pressure. It relaxes the walls of your blood vessels, allowing them to widen.
Yes if you take too many pills your blood pressure may drop dangerously low.
This can vary depending upon how well your kidneys function, but generally after 3-10 hours, only half of the Perindopril is left in your system.
No, Perindopril is an ACE-inhibitor. Both calcium channel blockers and ACe-inhibitors can reduce blood pressure, but they work via different mechanisms
Coughing is the most common side effect of Perindopril. If this side effect bothers you, you should discuss this with your doctor.
Yes, ACE-inhibitors are often combined with other antihypertensive medications such as calcium channel blockers.
Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.
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