Get immediate medical help if you experience signs of an allergic reaction to Rabeprazole: skin rash (which may be itchy), swelling of your face, lips, tongue, throat; difficulty breathing.
Common side effects include:
- Nausea (feeling sick)
- Vomiting (being sick)
- Gas and stomach pain
- Sore throat
If any of these side effects persist or cause distress, talk to your doctor.
Rare but serious side effects include:
- Abnormal changes in your skin such as rash on nose, cheeks and arms, blisters and new or worsening joint pain (possible signs of Lupus)
- Worsening stomach pain, yellowish skin, whites of your eyes turn yellow, dark urine (possible signs of liver problems)
- Unusual weakness, sore tongue, numbness/tingling of the hand and/or feet (possible vitamin B-12 deficiency)
- Pain when you urinate, changes in the amount you urinate, lower back pain, swollen ankles, rash, fever (possible signs of kidney problems)
- Infections (sore throat, fever), or ulcers in your mouth or throat
If you experience any of these rare but serious side effects, seek immediate medical help.
Rabeprazole is contraindicated if you suffer from any of the following conditions:
- Clostridium difficile infection (a common bacterium of the human intestine that can infect the bowel and cause diarrhea)
- Inadequate vitamin B12
- Low amount of magnesium in the blood
- Liver problems
- Interstitial nephritis (when the spaces between the small tubes inside the kidney become inflamed)
- Subacute cutaneous lupus erythematosus (skin disease that commonly develops in sun-exposed areas, including the upper back, shoulders, extensor arms, neck, and upper torso, while the face is often spared)
- Systemic lupus erythematosus (chronic disease that causes inflammation in connective tissues, such as cartilage and the lining of blood vessels)
- Osteoporosis (condition that weakens the bones)
- CYP2C19 poor metabolizer (an enzyme which metabolizes certain medications, and can work differently in people with genetic predisposition)
- Allergy to Proton Pump Inhibitors (group of drugs in charge of reducing stomach acid production)
Some medicines should not be taken in combination with Rabeprazole. Do not use Rabeprazole in combination with anti-diarrhea products or narcotic pain medications (painkillers) as Rabeprazole may worsen the symptoms you seek to treat. Call your doctor if you develop persistent diarrhea, abdominal stomach pain/cramping, fever, or blood/mucus in your stool. Also, do not use Rabeprazole in combination with the following medicines as they may increase the risk of side effects: Digoxin (for heart conditions), antifungal medicines (Itraconazole, Ketoconazole, Posaconazole), Methotrexate (for cancer and conditions like psoriasis and rheumatoid arthritis), HIV drugs, Rifampicin (antibiotic), or antidepressants. Before taking Rabeprazole, inform your doctor of all the medicines you are currently taking.