This article is about Sertraline (Zoloft) which can be used to treat male premature ejaculation. If you are dealing with premature ejaculation, doctors at Medzino can issue a prescription for Sertraline.
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Written by Dr Yasmin Aghajan, MD
Information last reviewed 06/21/19
Premature ejaculation which is defined by quick ejaculation (1-2 minutes), inability to delay or control ejaculation, and distress about the condition. There are several options for treatment. The first choice for treatment is Sertraline. Other options include numbing cream such as Lidocaine/Prilocaine (EMLA).
Sertraline is a medication of the selective serotonin reuptake inhibitor (SSRI) class. It works by increasing the amount of serotonin that neurons can use. Although it can be used for premature ejaculation, it is most commonly used to treat depression, anxiety, posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), and social anxiety disorder.
Sertraline is approved in the treatment of depression, PTSD, OCD, and panic disorder. It is prescribed off-label for premature ejaculation.
The active ingredient in Sertraline is sertraline hydrochloride (25, 50, or 100mg).
The inactive ingredients include: dibasic calcium phosphate dihydrate, D & C Yellow #10 aluminum lake (in 25 mg tablet), FD & C Blue #1 aluminum lake (in 25 mg tablet), FD & C Red #40 aluminum lake (in 25 mg tablet), FD & C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide. Inactive ingredients may vary by manufacturer.
The proper dosage for Sertraline for premature ejaculation is between 50mg and 200mg per day. It should increased as needed every four weeks. There is no dosage adjustment for kidney disease. Do not stop taking Sertraline before talking to your doctor.
There is an FDA warning for this class of medication that it can increase the risk of suicidal thoughts and behavior in young adults. Sertraline may cause increased bleeding, impair cognitive function (use caution while driving or operating machinery), narrow-angle glaucoma in susceptible individuals, and serotonin syndrome which is a potentially life -threatening condition when SSRIs are used in combination with other serotonin agents. Always tell your doctor what medications and supplements you are taking. SSRI medications may cause low levels of blood sodium which could be life-threatening.
The most common side effects were insomnia (20%), dizziness (12%), fatigue (12%), drowsiness (11%), nausea (26%), diarrhea (20%) and dry mouth (14%).
Less common side effects include palpitations, agitation, malaise, sweating, decreased libido, erectile dysfunction.
Sertraline is known to have interactions with the following medications:
Sertraline is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), and in patients with an allergy to Sertraline or its other ingredients.
Sertraline was approved in 1991, and is one of the most prescribed medications in the United States.
Sertraline, or Zoloft, is manufactured by Pfizer. However, it is available as a generic medication as well.
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