What is Sertraline used for?

A complete guide to Sertraline (Zoloft)


What is Sertraline?

Sertraline is an SSRI (selective serotonin reuptake inhibitor) antidepressant that’s approved by the U.S. FDA and available by prescription to treat a range of psychological disorders. It’s been used for treating clinical depression and other conditions since 1991 and at first was marketed by Pfizer as Zoloft. Today, generic versions are widely available, but Zoloft remains the most well-known trade name. Sertraline is taken orally and comes in doses of 25mg to 100mg. A typical daily dose when used as an antidepressant is 50mg.

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Currently, sertraline in the U.S. market is FDA-approved to treat the following conditions:

  • Major depression 
  • Obsessive-compulsive disorder (OCD)
  • Social anxiety
  • Panic anxiety
  • Post-traumatic stress disorder (PTSD)
  • Premenstrual dysphoric disorder (PMDD)


Aside from this list, doctors also prescribe sertraline for off-label purposes, such as treating sleep disorders, postpartum depression, and premature ejaculation. 

In 2017, some 37.1 million sertraline prescription were issued in the United States alone, making the antidepressant one of the top 50 prescribed drugs in the country. 


What does Sertraline do to the body?

Sertraline, like all other SSRI (Prozac, Paxil, etc.), increases serotonin levels in the brain. Serotonin, which is known as the “happiness hormone”, is a neurotransmitter that — among a lot of other functions — sends information back and forth between nerve cells in the brain.  Higher serotonin levels in the brain are associated with feelings of happiness and general mental wellbeing; with low levels correlating with depression and other psychological problems. 


Once a molecule of serotonin is done transmitting information to a brain nerve cell, it will be reabsorbed (i.e., converted into other chemicals). SSRIs block this reabsorption, hence they are named “inhibitors”.  Blocking reabsorption causes serotonin levels in the brain to rise, which may then ease depression or ease anxiety, and improve mental wellbeing in general.


Sertraline’s effect in delaying ejaculation was discovered as an unintended side effect. It can help men who feel they ejaculate too quickly during sexual encounters. Consequently, itmay also lower sexual appetite and sdecrease sensitivity, which can be a problem for men who do not suffer from premature ejaculation. 


How long does it take for Sertraline to take effect?

When used as an antidepressant, it will take weeks to months for sertraline to yield measurable improvement. Not only do serotonin levels need to be built up, but it takes time for the serotonin to alter emotional processing in the brain. A British study done in 2015-2017 on 655 patients found that a noticeable improvement of depression symptoms became apparent (compared to a control group) only after 12 weeks of treatment. Earlier studies came to similar conclusions.


Sertraline may be prescribed for several years when required for major depression. Even after s patient no longer has any depression symptoms, many doctors continue prescribing sertraline for another 6-12 months in order to avoid a relapse. 


Sertraline works a bit faster for anxiety disorder; usually the first improvements show up after six weeks of treatment, with patients becoming calmer and worrying less. Since depression and anxiety go hand-in-hand, sertraline’s early effect on anxiety symptoms also benefits the treatment of depression in the long run. 


When taking sertraline to treat premature ejaculation, the effect of the drug is much more immediate. Usually it’s a matter of a few hours. Therefore, you caan use sertraline on an as needed basis, by taking 50-100mg of sertraline 4 to 8 hours prior to sexual activity. It is however, more effective to take sertraline daily, in which case, the full effect of the medication is felt at approximately 3 weeks.


What are the most common side effects of Sertraline?

Sertraline is a powerful chemical and thus has a broad range of potential side effects. Fortunately, serious side effects are rare, and even the mild side effects usually are limited to the first 3-4 weeks of treatment. Once sertraline has reached a stable level in your body and brain, these side effects tend to disappear. 


If you only take sertraline occasionally prior to sex — for example 5-8 single doses a month — to treat premature ejaculation, the risk and intensity of side effects is reduced.

It is important to be aware of what major side effects can be and how to notice them. Here’s a list of the most common side effects:  


Sexual side effects: Some 40-65 percent of sertraline users experience lower libido or orgasm difficulties during the initial weeks of sertraline treatment. Both men and women can be affected by this. These effects wear off with time as your body acclimates to the sertraline. 


Dizziness: During the first several weeks on sertraline you may feel a mild dizziness or lightheadedness. This is more common for people who take sertraline in the morning hours. Try switching your daily dose to the evening instead. For most people this improves the daytime dizziness. 


Sleep problems: Like all SSRIs, sertraline can affect the quality of your night sleep. You may find it harder to fall asleep or suddenly wake up at night. Once again, this is a short-term effect of sertraline and will eventually go away. Avoid coffee, energy drinks, and caffeinated sodas during the first month of taking sertraline, as this could exacerbate the sleeping problems.

Diarrhea: During the initial weeks of sertraline use, diarrhea and other gastrointestinal issues can be a common side effect. Studies show that some 15 percent of users experience diarrhea or milder bowel irritations.


All the above discussed side effects normally resolve dafter the first months of sertraline treatment, although the effect on premature ejaculation may persist at the right dose.  If there is no improvement in symptoms by the second month of treatment, ask your doctor for help. He or she may be able to switch you to another SSRI or prescribe medication that alleviates the side effects.


Seek immediate medical assistance if you start having suicidal thoughts or feel aggressive. Such thoughts and feelings can be a rare side effect of sertraline. It’s mostly only seen in people aged 24 or younger, but it’s a good precaution to be alert. During your first few weeks on sertraline or other SSRIs, tell your doctor about any mood and behavior changes you yourself or your loved ones notice.   


Don’t take sertraline when you are pregnant or planning to become pregnant soon, as this increases the risk of miscarriage and other complications. Studies indicate that sertraline can be used safely during breastfeeding.


To learn more about other potential side effects of sertraline not mentioned here, speak with a doctor or refer to the manufacturer’s package insert. 


What’s the best time of the day to take Sertraline?

If you use sertraline as needed for the purpose of delaying ejaculation, you want to take it 4-8 hours prior to having sex. 


When taking sertraline to treat depression, most people take their daily dose either in the morning or evening. Which time you choose depends wholly on the side effects you experience during the initial treatment month. If taken in the morning, there’s a greater risk of daytime dizziness, and when taken in the evening it may reduce your sleep quality. At first, try the mornings for a week or two. If that doesn’t make you feel dizzy, continue with the morning schedule. Otherwise, switch to taking sertraline in the evening and see whether it affects your sleep. Ultimately, you have to opt for the time of the day that is likely to give you the least side effects. If in doubt, ask your doctor how to best take sertraline. 


Where can I buy Sertraline?

Sertraline isn’t available over the counter, as it is a potent medication with risk of complications.  It requires a prescription by a licensed doctor. It’s usually in stock in all major pharmacies and readily available once you show the pharmacist your prescription.  


Another, perhaps more convenient, way to get sertraline is through an internet pharmacy, which can also save you time and money. Most legal online pharmacies have licenses allowing them to prescribe a wide range of prescription-only medications. For this purpose they employ licensed doctors and/or pharmacists. Consultations are often free-of-charge. Check the website of the Board of Pharmacy in the state you live in to see whether an internet pharmacy is licensed to issue medical prescriptions.



  1. Lewis, Gemma, et al. “The Clinical Effectiveness of Sertraline in Primary Care and the Role of Depression Severity and Duration (PANDA): A Pragmatic, Double-Blind, Placebo-Controlled Randomised Trial.” The Lancet Psychiatry, vol. 6, no. 11, Nov. 2019, pp. 903–914, Accessed 16 Dec. 2019.
  2. Cipriani, Andrea, et al. “Comparative Efficacy and Acceptability of 21 Antidepressant Drugs for the Acute Treatment of Adults with Major Depressive Disorder: A Systematic Review and Network Meta-Analysis.” The Lancet, vol. 391, no. 10128, Apr. 2018, pp. 1357–1366, Accessed 1 Mar. 2019.
  3. Arafa, Mohamed, and Rany Shamloul. “A Randomized Study Examining the Effect of 3 SSRI on Premature Ejaculation Using a Validated Questionnaire.” Therapeutics and Clinical Risk Management, vol. 3, no. 4, 2007, pp. 527–31, Accessed 16 Dec. 2019.
  4. Jing, Elizabeth, and Kristyn Straw-Wilson. “Sexual Dysfunction in Selective Serotonin Reuptake Inhibitors (SSRIs) and Potential Solutions: A Narrative Literature Review.” Mental Health Clinician, vol. 6, no. 4, July 2016, pp. 191–196, Accessed 16 Dec. 2019.
  5. McMahon, C G. “Treatment of Premature Ejaculation with Sertraline Hydrochloride.” International Journal of Impotence Research, vol. 10, no. 3, 1998, pp. 181–4; discussion 185,, Accessed 16 Dec. 2019.

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