Metoclopramide is a prescription drug recommended for patients who suffer from symptoms of nausea and vomiting that are typically accompanied with cluster or chronic migraines. Sold under
the brand name Reglan, the medication may also increase the efficacy of painkillers and migraine medication by accelerating the rate at which they are absorbed into the bloodstream.
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Metoclopramide is an antiemetic (anti-sickness) drug that essentially prevents unwanted symptoms, commonly associated with migraines, such as nausea and vomiting. The medicine interacts with dopamine receptors found in the brain, which are responsible for inducing nausea. It can also increase the efficacy of medication used to treat migraines such as Topiramate and Propranolol, among others. Having received its FDA approval in 1985, the drug is sold under the brand name Reglan and is available as either a standard or dissolvable tablet, in liquid form, or an injectable solution.
Although Metoclopramide is primarily indicated for the treatment of gastrointestinal (GI) issues such as heartburn, acid reflux and a slow-moving GI tract (gastroparesis), it is also used by those who experience nausea and vomiting caused by migraines as the symptoms are a prime commonality of these conditions. The medication may also be used to prevent sickness stimulated by medical procedures including anti-cancer chemotherapy, radiotherapy and surgical procedures.
Metoclopramide is classed as a dopamine antagonist which works by blocking dopamine receptors found in a part of the brain known as the chemoreceptor trigger zone (CTZ). When the CTZ detects an irritant, it responds to nerve messages between the brain and the stomach, subsequently triggering the vomiting reflex. By blocking the dopamine compounds in the CTZ, the nausea-inducing signals are prevented from reaching the stomach, thus counteracting the sensation of sickness and vomiting.
Furthermore, the stomach’s ability to empty itself can be inhibited during a migraine attack, thus preventing the effective absorption of oral painkillers or migraine medication. Metoclopramide can be taken to facilitate the passage and absorption of such drugs through the digestive system and ultimately increase its efficacy for migraine relief.
Metoclopramide is a prescription drug and therefore not available to purchase over the counter in the United States. Medzino offers Metoclopramide in 10 mg strength and in quantities of 30 standard tablets. We are able to offer first and repeat prescriptions to patients, specifically for the reduction of nausea and vomiting that can accompany severe migraines. Our doctor’s will assess your symptoms through our online consultation service and subsequently individualize your treatment and dosage.
Once ingested, Metoclopramide tablets typically begin to take effect after 30 to 60 minutes. Symptoms of nausea and vomiting should subside 1 to 3 days after starting the treatment.
The active ingredient in Metoclopramide is metoclopramide hydrochloride.
The inactive ingredients in Metoclopramide are magnesium stearate, cellulose, microcrystalline, mannitol and stearic acid.
Metoclopramide can be taken with or without food and should be swallowed with a drink of water. If you have difficulty swallowing the tablet whole, you may break it along the score line before ingesting.
Always take Metoclopramide as ordered by your doctor and ensure to follow the instructions on the patient information leaflet. Do not take more or less than the prescribed amount or longer than your doctor has ordered as doing so may increase the chance of adverse side-effects.
For the symptomatic treatment of nausea and vomiting associated with acute migraines, a single 10 mg dose of Metoclopramide should be administered at the onset of the migraine symptoms; the maximum daily dose should not exceed 30 mg.
In order to avoid an overdose, you must wait a minimum of 6 hours between each dose of Metoclopramide, even in cases of vomiting and rejection of the medicine.
The above dosage and directions may need to be adjusted for children, older people or those with kidney and liver problems.
In order to avoid serious side-effects and reactions, the maximum duration of treatment with Metoclopramide must be no more than 5 days at a time and overall treatment should not exceed 12 weeks. If your symptoms persist or worsen, consult your doctor immediately.
Continue taking Metoclopramide as your doctor has advised – even if you experience relief from your symptoms. If you want to discontinue your treatment, always speak with your doctor first who will advise you on the best way to do so. You may experience withdrawal symptoms such as dizziness, nervousness, and headaches when you stop taking the medication.
If you forget to take a dose of Metoclopramide, take it as soon as you remember; however, if you are nearer to your next scheduled dose, skip the missed dose altogether. Do not double doses to make up for one that you have missed.
If you have taken more Metoclopramide tablets than prescribed, contact your doctor or pharmacist immediately. Symptoms you may experience from an overdose include:
Your doctor may prescribe you additional medication for the above signs, if necessary.
Although Metoclopramide is generally well-tolerated when taken in low doses over a short period, it may trigger certain side-effects in long-term users or those who ingest it in high doses, although not everyone will experience them.
The most common side-effect of Metoclopramide is drowsiness, affecting more than 1 in 10 users, and should not be a cause for concern.
Other common side-effects include (affecting up to 1 in 10 people):
Uncommon side-effects include (affecting up to 1 in 100 people):
Metoclopramide, in extremely rare cases, may cause a serious condition known as Neuroleptic Malignant Syndrome (NMS). Seek medical attention immediately if you experience symptoms including:
Always inform your doctor if your symptoms persist or worsen, including any that are not listed above.
Prior to taking Metoclopramide, you must inform your doctor of your full medical history, including:
Treatment with Metoclopramide may cause a condition known as tardive dyskinesia; a disease that triggers abnormal and uncontrollable muscle movements in the face and body, and is often irreversible – even if the drug is stopped. Patients who take the medication in high doses and over prolonged periods are at a greater risk of developing the disease, as well as children and older adults. Discontinue usage and call your doctor immediately if you experience any involuntary body movements such as sticking out of the tongue, puffing cheeks, lip smacking or chewing.
As Metoclopramide may cause dizziness and/or drowsiness in some users, it is advised not to drive, operate heavy tools or machinery, or engage in any activities that require alertness until the affects have completely worn off.
Consuming alcohol during treatment with Metoclopramide may increase the drugs sedative effects. It is therefore advised to considerably reduce your alcohol intake or avoid it altogether whilst medicating.
For women who are pregnant, or planning to become pregnant, it is important to always seek your doctor’s advice prior to taking Metoclopramide. Although the medication has no known effects on the developing foetus, it should only be taken if considered essential.
Metoclopramide is not recommended for women who are breastfeeding as the drug passes into the breastmilk in small amounts and may have an effect on the baby.
Metoclopramide is not recommended for those who have, or previously had:
When certain drugs are taken in combination, their efficacy may be reduced, or cease completely; it could also produce serious and adverse side-effects. Before beginning treatment with Metoclopramide, you must inform your doctor of all other medication you are currently taking, including any prescription and over-the counter drugs as well as any vitamin or herbal supplements, particularly:
If, for any reason, you are unsuited to Metoclopramide, consult your doctor or pharmacist about alternative medication you can take to effectively treat the symptoms of nausea and/or vomiting associated with migraines.
While there are many treatment options available for treating nausea and vomiting, not all are intended for sickness related to symptoms of migraines.
The most effective remedy will depend on the severity of your symptoms, your medical history, as well as your response to the medication. Listed below are a few viable options; however, speak with your doctor for a comprehensive list of alternative treatments, to establish which one will work best for you.
This is an antihistamine drug which works by blocking natural substances in the brain that trigger the sensation of nausea. However, the medication may not be suited to those who suffer certain conditions including asthma, low or high blood pressure, heart disease, or a weak immune system.
This is an antipsychotic drug which is also licenced for treating and controlling nausea and vomiting. It works by restoring balance in the natural chemicals found in the brain; however; it may induce side-effects similar to that of Metoclopramide including uncontrollable body movements.
Similar to Metoclopramide, this drug also helps relieve nausea and vomiting by interacting with the dopamine receptors in the brain. Its common side-effects include confusion, dizziness, digestive upset and excitability.
This drug is derived from cannabis and can be used to treat sickness that cannot be controlled by other antiemetic medication. While the drug is effective, it may cause drowsiness or dizziness in some users, which may last for a few days after you have stopped taking it.
It is always best to consult your doctor in this case. A small number of studies proved that Metoclopramide does not cause miscarriage or the chance of birth defects in children. However, it can cause nausea, vomiting and gastrointestinal discomfort.
Metoclopramide causes an increased in prolactin levels in the blood when used over a long period of time. It may cause breast swelling, milk production, soreness and irregular periods. It may also cause loss of libido and sexual performance.
Metoclopramide can also be prescribed to patients with diabetes who suffer from gastroparesis (slow emptying of the stomach). It is used to help reduce the symptoms of nausea vomitting and abdominal fullness. It is currently the only FDA approved drug to help gastroparesis.
In people with normal kidneys function, Metoclopramide stays in the system for about 33 hours. It has a half-life of about 5-6 hours. For Metoclopramide to be fully flushed from the system it takes 5.5 times the half-life of the medication which is 5.5x6 hours (33 hours).
Metoclopramide injection is used for purposes of chemotherapy. It can also be given intravenously. When it is, it is given in a small volume usually over 3 minutes. It is used to help subside the effects of nausea and vomiting caused by chemotherapy. It can also be used before certain procedures to aid in the emptying of the intestine.
Disclaimer: This is not medical advice. You and your physician will determine if and how you should take any medication prescribed to you following a medical consultation.
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